I've successfully completed two awesome Metroamp JTM-45's.

I'm thinking of going to a 50 watt Plexi now for a different flavor. I love to play my roots music--classic rock, ala Clapton, Hendrix, Dobbies, Thin Lizzy, Queen.
I'm a huge blues rock enthusiast and am now setting up a home recording studio.
The "problem" is, I own a vintage, mint condition Musicman 112 Sixty Five (EL34 Telefunkens). I'm wondering if I might be covering the same territory with the 50 watt Plexi. Would you recommend the 50 watt or another Metroamp kit build for my classic blues rock style?
I've been using an Avatar 2x12 with G12-65's. It's now on tour with one of the pros, but I would now like to try a 4x12 with Celestion Blues or Greenbacks, or even a combination. Has anyone combined Blues with Greenbacks?
I'd be interested in your input. Thanks in advance!